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KMID : 0882419780210050387
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Korean Journal of Medicine
1978 Volume.21 No. 5 p.387 ~ p.411
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A Study on the Blood Level of Digoxin and Digitoxin by the Radioimmunoassay Method
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Park Jeong-Euy
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Abstract
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A radioimmunoassay for serum digoxin and digitoxin concentration has been used in 151 patients and normal volunteers to study the clinical pharmacology of digitalis and determine the serum concentration in nontoxic and toxic patients.
The results obtained are as follows.
1. For normal volunteers, mean serum digoxin concentration was 0.51±0.09 ng/ml on 0.25 mg daily
maintenance and 1.00±0.26 ng/ml on 0.5 mg. Mean serum digitoxin concentration was 26.25±3.96 ng/ml on 0.1 mg daily maintenance and 43.75±16.10 ng/ml on 0.2mg.
2. For patients, mean serum digoxin concentration was 0.32±0.29 ng/ml on 0. 125 mg daily maintenance, 0.58±0.24 ng/ml on 0.25 mg, 0.53±0.25 ng/ml on 0.375 mg and 0.98±0.30 ng/ml on 0.5 mg. Mean serum digitoxin concentration was 16.03±2.80 ng/ml on 0.1 mg.
3. Mean serum digoxin concentration in 19 pediatric patients was 1.1± 0.88 ng/ml.
4. There were 15(9.9%) underdigitalized patients (serum digoxin concentration <0.3ng/ml) among total 151 digitalized patients.
5. There were 7(4.6%) definitely digitalis intoxicated patients by EKG criteria among total 151 digitalized patients.
6. In toxic patients mean serum digoxin concentration was 1.96±0.77 ng/ml and was significantly high compared with nontoxic patients.
7. 97.9% of patients without evidence of toxicity had serum concentrations of 1.6 ng/ml or less, while 70% of the toxic group had levels above 1.6 ng/ml.
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KEYWORD
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